Walden Bioscience is a privately held, venture capital backed company with a mission to transform the treatment of kidney disease by reversing its progression and enabling and inspiring patients to resume their normal lives. We are developing first-in-class, highly targeted therapies for individuals living with both acute and chronic renal diseases. Our objective is to transform the treatment of renal diseases, providing patients with treatment options where currently few exist. You will have a great opportunity to help us bring this important mission to life.
- Design and source DNA constructs used for protein expression and purification
- Formulate screening and selection strategies for protein engineering
- Establish and maintain instrumentation and laboratory equipment and supplies necessary for protein production and purification
- Conduct protein expression and purification work to generate reagents to support biologics and small molecule drug discovery
- Work independently on the design and execution of experiments
- Collaborate closely with multiple cross-functional project teams
- BA with 6-8 years or MS with 4-6 years relevant industry experience Biochemistry, Molecular Biology or Bioengineering-related field
- Required: ability to design DNA constructs for protein expression studies and outsource generation
- Required: experience with recombinant expression, purification and characterization of antibodies and other proteins using a range of expression systems (In vitro, E. coli, insect cell, mammalian cell, etc.)
- Required: experience with characterization of protein products and troubleshooting for proper protein folding and solubility
- Preferred: Experience with discovery and affinity maturation of antibodies using phage panning
- Preferred: ability to carry out plate-based biochemical reactions (eg. ELISA, enzyme reactions, protein binding, etc) to evaluate protein binding/function
- Experience with coupled transcription translation is an advantage.
- Ability to multi-task to meet technology development and research goals
- Strong quantitative analysis skills as well as excellent written and oral communication
- Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
At Walden Biosciences, we are relentlessly focused on developing first-in-class, highly-targeted therapies for individuals living with kidney disease. Our accomplished team members are expert drug hunters and we have strong financial backing from blue chip investors.
Our culture is collaborative and entrepreneurial, and our team is dynamic and driven by data and innovation. We want to make the best decisions with the best available information, lead by example and bring transformative medicines to patients in need.
Walden Biosciences is based in the heart of Cambridge, MA between Harvard, Massachusetts Institute of Technology (MIT), and Massachusetts General Hospital.
Join us for a professional experience like no other, as we seek to bring patients the first therapies targeted to the kidney.