Sr Scientist / Associate Director, Protein / Antibody Engineering

Your Opportunity:

Walden Bioscience is a privately held, venture capital backed company with a mission to transform the treatment of kidney disease by reversing its progression and enabling and inspiring patients to resume their normal lives. We are developing first-in-class, highly targeted therapies for individuals living with both acute and chronic renal diseases. Our objective is to transform the treatment of renal diseases, providing patients with treatment options where currently few exist. You will have a great opportunity to help us bring this important mission to life.

As a key member of our Molecular Sciences team, the Sr. Scientist / Associate Director, Protein / Antibody Engineering is responsible for discovering and developing novel therapeutic antibodies and proteins. The position reports into Head of Molecular Sciences and Information.

Responsibilities:

Experience with protein engineering to facilitate small molecule chemistry-based drug screening
Conduct cutting-edge research to develop novel antibody-based candidate therapeutics including developing novel scaffolds and antibody libraries
Working knowledge of different antibody engineering approaches, understand different capabilities of these technologies and be able to execute or contract them appropriate to project needs
Measure aggregation, solubility, stability and other parameters related to the manufacturability of candidate antibody therapeutics
Produce purified candidate antibody therapeutics in quantities sufficient for animal studies
Perform flow cytometry and sorting or other screening platforms
Align and inspire more junior staff including technicians

Qualifications:

Ph.D. in Molecular Biology, Immunology, Biochemistry, Cell Biology, or related field with a minimum of 5 years’ of antibody / protein engineering experience in a biotech/pharmaceutical environment
A track record of driving therapeutic antibody / protein programs from early discovery into development stage
Extensive experience with phage or yeast display, flow cytometry and sorting, SPR, epitope binning and protein biochemistry
Strong knowledge in antibody structural modeling, sequence prediction, and strong understanding of protein structure-function relationships
High throughput screening, registering sequences and data management
Experience building a positive, team-oriented culture with strong leadership and communications skills
Strong passion for innovating and forward-thinking based on competent experimentation and reliable data
Demonstration of leadership, problem solving, decision-making, and project management skills
Open, highly collaborative and scientifically curious

About us:

At Walden Biosciences, we are relentlessly focused on developing first-in-class, highly-targeted therapies for individuals living with kidney disease. Our accomplished team members are expert drug hunters and we have strong financial backing from blue chip investors.

Our culture is collaborative and entrepreneurial, and our team is dynamic and driven by data and innovation. We want to make the best decisions with the best available information, lead by example and bring transformative medicines to patients in need.

Walden Biosciences is based in the heart of Cambridge, MA between Harvard, Massachusetts Institute of Technology (MIT), and Massachusetts General Hospital.

Join us for a professional experience like no other, as we seek to bring patients the first therapies targeted to the kidney.