CAMP4 is seeking a passionate and innovative scientist to join a team responsible for enabling the expansion of CAMP4’s Gene Circuitry PlatformTM across a broad spectrum of primary human cell types utilizing state-of-the-art genome interrogation technologies. In this role, you will work closely with experimental and data scientists to elucidate transcriptional mechanisms responsible for investigational compounds’ effects on disease gene expression and advance the evidentiary and predictive principles of gene control across cell-types, modalities, and therapeutic areas. You will be a creative, flexible scientist with a demonstrated ability to adapt to changing priorities who has a passion for realizing the potential of fundamental scientific discoveries to improve patients’ lives.

In this role you will

  • Investigate the transcriptional mechanism underlying the therapeutic effects of pre-clinical candidates developed for a variety of therapeutic areas, including liver, muscle, heart, kidney, brain and immune disorders
  • Generate multi-dimensional data types capturing the dynamic and spatial complexity of transcriptional regulation across relevant conditions, stimulation and treatment paradigms
  • Collaborate closely with other experimental and data science colleagues to guide mechanism-driven drug development, including in the context of biotech collaborations and publications
  • Provide significant conceptual input into experimental design and analysis plans and engaging in cross-functional discussions to refine plans and identifying key priorities
  • Obtain experimental results as specified by analysis plans and provide interpretation and context to results of analysis
  • Identify, evaluate, and apply new methodologies and emerging technologies, and develop new technological tools necessary to enable target identification
  • Demonstrate an exceptional work ethic by taking the initiative and working with a sense of urgency to discover breakthrough medicines that will improve patients’ lives, collaborating and sharing ideas with the rest of the team, and challenging the status quo

Who You Are

  • Must have a Ph.D. in Molecular Biology, Cell Biology, or related field
  • 3+ years of industry experience along with a relevant academic background (preferably involving primary human cells)
  • Experience managing and training junior colleagues
  • Extensive hands-on experience with next generation sequencing (NGS) and techniques for genomic analysis of DNA (ChIP-seq,ATAC-seq, whole-genome sequencing), DNA interactions (ChIA-PET, Hi-C, Hi-ChIP), and gene expression (conventional and single-cell RNA-seq, GRO-seq/PRO-seq)
  • Good understanding of gene editing tools and principles (ZFN, TALEN, CRISPR, or DNA base editors). Previous experience optimizing CRISPR/Cas9-based gene editing is strongly preferred
  • Recognized excellence as evidenced by top-tier peer-reviewed publications in the area of gene control, chromatin biology, and epigenetics and strong references
  • Strong collaboration and ability to work cross-functionally
  • Effective project management, planning and attention to detail
  • High professional integrity and a proven commitment to excellence in execution
  • Excellent communication and presentation skills

Who We Are

Founded in 2016 and focused on a core mission of realizing a world with ‘an effective treatment option for every patient,’ CAMP4 Therapeutics evolved from seminal discoveries made by company founders Dr. Richard Young and Dr. Leonard Zon, characterizing the ways in which dynamic cell signaling networks control the expression of genes. Operating at the intersection of genomics, computational biology, and data sciences, CAMP4 has extended this foundational work, creating a unique Gene Circuitry PlatformTM to amplify the value of cellular and genetic insights to better understand how genes are controlled by signaling pathways in specific disease states. By generating proprietary 4D maps, CAMP4 can identify de-risked druggable targets, produce actionable insights, and improve therapeutic predictability, potentially addressing hundreds of diseases and benefiting millions of patients globally.