Inscripta is searching for an experienced Scientist to join our Product Development team. A candidate with a proven track record of designing and developing novel measurement tools and assays that enrich for and quantify nucleic acids, will become a lead contributor to integrated, multidisciplinary teams developing new CRISPR-based, DNA editing technology platforms (software, instruments, and reagents). As a successful candidate, you will work in a dynamic, team-oriented environment to create cutting-edge technology that enables scientific discovery and advancement.
- Lead the design and development of novel methodologies that enrich for and/or quantify nucleic acids using NGS and droplet digital PCR technology, with a focus on enabling single cell nucleic acid measurements.
- Develop and validate robust, novel assays to measure integrated system performance for product development and commercialization.
- Perform Gauge R&R, verification, validation & transfer from R&D to manufacturing.
- Interface with third party analytical labs when needed to plan experiments and analyze results.
- Work collaboratively with biochemists, molecular biologists, enzymologists, engineers, and bioinformaticians to identify and develop appropriate controls and measurement processes.
- Present clear and concise written and oral communications to colleagues and supervisors, lead and/or participate in technical meetings, and provide recommendations based on technical results.
Required Educational Background and Work Experience:
- PhD in Biochemistry, Molecular Biology, or a closely related field.
- Minimum of 2 years of experience working in a commercial product development role.
Required Skills and Experience:
- Hands-on experience with NGS sample prep and novel NGS assay development; special consideration will be given to candidates who have breadth of experience with single cell NGS technology and methods (e.g. 10X Genomics single cell applications, DART-seq, SCI-seq, etc.).
- Demonstrated experience solving challenging, interdisciplinary research and development problems at the interface of biology, chemistry and materials science.
- Broad knowledge of tools and techniques used for nucleic acid isolation, enrichment and quantitation.
- Strong foundation in measurement science.
- Strong skills in the design and execution of experiments, and statistical analyses of the resulting data; special consideration will be given to candidates with quantitative, applied mathematics experience in probability theory, multivariate calculus, and advanced topics in analytical chemistry.
- Experience with developing and transferring manufacturing-friendly metrology.
- Hands-on experience in development and testing of prototype through production-ready reagents and instrumentation.
- Experience in at least one programming or scripting language such as R, Python, or Matlab.
- Demonstrated ability to adapt to and overcome technical challenges in a fast-paced environment within an interdisciplinary team setting.
Desired Skills and Experience:
- Hands-on experience with developing novel droplet digital (ddPCR) assays.
- Experience with genome engineering techniques and methods.
- Hands-on laboratory experience with some or all of the following techniques: cell lysis and nucleic acid isolation, molecular cloning, transformation, transfection, cell culture, qPCR, gel electrophoresis and nucleic acid size selection and quantitation methods.
If this job sounds like a solid fit, you want to work in high growth company with proven success, and be part of an entrepreneurial organization, e-mail your resume to firstname.lastname@example.org and tell us why Inscripta should hire you. Inscripta is headquartered in Boulder, CO with an additional location in Pleasanton, CA.