Who We Are

Kinnate is a rapidly growing, clinical stage precision oncology company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers. Kinnate’s mission is to expand the reach of targeted therapeutics by developing products for underserved populations.  With our lead RAF and FGFR programs currently conducting Phase 1 clinical trials, it is a very exciting time to join Kinnate!   In addition to the promising developments in our pipeline, Kinnate is financially strong with approximately $324.9 million of cash, cash equivalents and investments as of December 31, 2021, which is expected to fund current operations, including initiation of multiple registrational studies, into the second half of 2023. Based in San Francisco and San Diego, California, the Kinnate team is composed of drug discovery experts supported by a distinguished group of scientific advisors.

Kinnate is an employee-focused company providing a best-in-class benefits package which includes:  cash salaries and bonuses and equity awards for all employees; employee stock purchase program; unlimited paid time off; annual paid “refresher” days for all employees; annual massage days for all employees; highly subsidized health benefits packages with a wide variety of provider options and minimal to no out of pocket expenses for employees; monthly stipend for employees who elect no health coverage through Kinnate; life and accidental death and disability insurance; company contribution to 401k plan; flexible office and remote work options; free local gym memberships; healthy lifestyle reimbursement program; home office reimbursement program; and commuter and walking/biking benefits. 

For more information, please visit www.kinnate.com.

Your Impact at Kinnate

We are seeking an Director / Associate Director of Clinical Development who will provide strategic and tactical medical leadership and oversight of clinical oncology studies, including engagement with academic and partner investigators, while ensuring compliance of all relevant regulatory guidelines.

Reporting to the Senior Medical Director, the Associate Medical Director will advance Kinnate’s lead compounds, as single agents or in rational combinations, into clinical trials of cancer patients with a range of solid tumors. The successful candidate will have a passion for novel science, an affinity for strategic thinking, an aptitude for looking beyond the day-to-day execution, and a record of leading early-stage and mid-stage clinical programs to critical milestones. 

S/he will provide key overall clinical and scientific leadership to clinical development programs while ensuring compliance with regulatory requirements and standard procedures.  The ideal candidate should have experience working in a fast-paced dynamic environment. This position can be based in either San Diego or San Francisco. 

Key Responsibilities:

·        Clinical/Medical leadership of global oncology clinical trials (Phase 1-3), ensuring that studies are carried out in accordance with the clinical development plan, GCPs, ICH and FDA and other regulatory and health authority requirements

·        Partner with Kinnate clinical leadership in creation of and revisions to Kinnate’s Clinical Development Plan (CDP)

·        Author and/or review clinical documents required for the conduct of clinical studies, including clinical protocols (and amendments), informed consent documents, investigator brochures, and safety management plans in compliance with regulations and good clinical practices

·        Assist in preparation of clinical sections of key regulatory documents, including INDs, IBs, annual safety reports and briefing packages, and lead clinical engagement with IRBs and Ethics committees

·        Prepare presentation materials for internal and external meetings, such as clinical team meetings, Scientific and Clinical Advisory Boards, and Board of Director Meetings

·        Provide clinical leadership in clinical study and program teams, and lead clinical communication to upper management on patient recruitment, trial issues, investigator's feedback, patient enrollment issues and presenting a plan of action for resolution of issues

·        Lead ongoing data review, analysis, and interpretation to understand safety and efficacy profile of the investigational drugs

·        Contribute to authoring and presentation of abstracts, posters, and oral presentations for scientific and clinical meetings

·        Collaborate with Kinnate clinical leadership, Clinical Scientist, and Clinical Operations group to identify and qualify global study sites and build strong professional relationships with study investigators

·        Present aspects of clinical program at Site Initiation Visits, Investigator's Meetings and scientific conferences

·        Serve as the first medical point of contact with sites: answer site questions about patient eligibility, enrollment, and provide clinical input into patient safety assessment and management

·        Review and assist creation of data analysis plans, case report forms (CRFs), study reference manuals, laboratory and biomarker manuals, patient diaries, and drug accountability forms

·        Review project specifications for IRT/IXRS, ePRO, Imaging Charter for Central radiology review and other procedural documents

·        Participate in ongoing clinical data cleaning and review and contribute to clinical study report drafting and/or review

·        Work together with the Clinical Scientist to ensure that above responsibilities are smoothly and efficiently carried out, to facilitate open, transparent communication both within the Kinnate team and with appropriate external partners, and to provide clinical expertise and support as needed to other line functions.

The Right Stuff: 

·        Medical Doctor (M.D. or equivalent) with Board Certification in Medical Oncology

·        Minimum of 2 years of oncology clinical drug development experience in either the pharmaceutical/biotechnology industries or in academia/fellowship

·        Early Phase (Phase 1 and 2) oncology clinical trial experience is strongly preferred (e.g., with emphasis on serving as the medical leader for trial programs for those with an industry background)

·        Thorough working knowledge of clinical trial design, methodology, and statistical concepts

·        In-depth knowledge of GCP/ICH guidelines

·        Working knowledge of the IND/NDA process is strongly preferred

·        Proven ability to provide leadership and positively influence diverse stakeholder groups across cross-functional teams, study investigators, key opinion leaders and the medical and scientific community

·        Available for periodic travel including domestic US and internationally as required.

Listed responsibilities are an essential, but not exhaustive, list of the expected initial duties associated with the position. The role will evolve over time and changes to individual responsibilities may occur due to business needs.

NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

Kinnate is a science-driven company and we are proud to be responsible members of our communities. Subject to applicable law, we require all of our employees to be fully vaccinated and boosted against the COVID19 virus.

 

EEO & Employment Eligibility

Kinnate Biopharma Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Kinnate Biopharma Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of applicable law.

Recruitment & Staffing Agencies: Kinnate Biopharma Inc. does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Kinnate or its employees is strictly prohibited unless contacted directly by Kinnate’s internal HR Team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Kinnate, and Kinnate will not owe any referral or other fees with respect thereto.