It’s an exciting time to join us!

The Andelyn Biosciences’ Preclinical Manufacturing Facility is seeking a motivated individual to join our growing team as an AAV Supervisor.


The AAV Supervisor is responsible for supporting the Viral Vector Core (VVC) Operations team by overseeing all aspects of AAV Manufacturing (USP and DSP).  This includes scheduling productions, ensuring the cell culture activities needed for productions are scheduled, working with team leads for USP/DSP activities, supporting the preparation and inventory of solutions, collaborating with supply chain for reagents/materials, and helping to organize the daily workloads.  The Supervisor will write and manage technical proposals for VVC productions and attend client meetings as necessary. The Supervisor will work with the Business Team to obtain critical production information and communicate technical information to clients and the team as needed.  The Supervisor will be responsible for assuring on-time completion of VVC productions and communicate possible solutions to the Director if there are impacts to the timeline.  The Supervisor will lead investigations and troubleshoot technical production issues as well as trend data and work with management to identify areas for process improvement.   


Schedule: Full-time (Benefits Eligible)  

Location:  Central Campus 

                  575 Children's Crossroads

                  Columbus, OH 43205 


Under the guidance and direction of the Associate Director - VVC, essential functions of the Supervisor include at a minimum:

  • Provide support leading a diverse team in day-to-day viral vector manufacturing activities (USP/DSP) and provide technical expertise.
  • Manage multiple schedules and employee performance management. 
  • Manage project flow from initial client contact to delivery of the final product.
  • The successful candidate must demonstrate personal leadership initiative, judgment, and accountability.  
  • Operate within the Quality System applicable to the manufacture of research-grade, toxicology grade, and engineering runs with grade appropriate material to support preclinical studies.
  • Maintain compliance with applicable regulatory and safety requirements for BSL2 lab and ensure delivery of high-quality gene therapy products.
  • Work with Supply Chain to manage inventory and materials (SAP), responsible for identification and approval of secondary source materials
  • Perform technical tasks as required, maintain documentation, and store records in accordance with established company policies, procedures, and protocols.
  • Ensure accurate documentation of all activities performed according to established SOPs.
  • Identifies problems, troubleshoots, and finds suitable solutions.
  • Manage decisions by acquiring feedback, input and consult as required.
  • Fiscal responsibility to work within budget and emphasis on reducing waste and increasing efficiency.
  • Write technical process plans, reports and proposals for all preclinical manufacturing and assist with RFP responses and proposals.
  • Consistently makes significant contributions to the achievement of the goals and objectives for the company and the team.
  • Work to establish improve processes to assure on time delivery (OTD) of deliverables.
  • Highly effective communication skills, both written and verbal.
  • Encourage a supportive team culture using our guiding principles and core values.
  • Demonstrate high level of integrity and adaptability.
  • Maintain positive attitude.
  • Work under general supervision of the Director.
  • Other duties as assigned.


Knowledge, Skills and Abilities required:

  • Bachelor’s degree with 8+ years relevant experience OR Master’s degree with 6+ years relevant experience OR Ph.D. with 1-2 years relevant experience required.
  • Hands-on experience with adherent and suspension mammalian cell culture for upstream production and/or downstream bioprocessing purification.
  • Demonstrate leadership, coaching and mentoring skills.
  • Highly effective communication and interpersonal skills.
  • Ability to work with highly confidential materials.
  • Demonstrate exceptional organizational, time management and problem-solving skills with an attention to detail.
  • Experience using single-use bioreactor systems, performing aseptic processes, and transferring manufacturing technology across departments a plus
  • Experience in Bioprocess Engineering, Gene Therapy, Biochemistry a plus.
  • Prior experience with viral vector research or manufacturing a plus.
  • Prior experience using SAP, Trackwise, ELN and LIMS a plus.
  • Skills in operating a personal computer.  Must be familiar with various software packages (e.g., Word, Excel, PowerPoint).


Minimum Physical Requirements

  • Sitting Constantly (0-67%)
  • Talking on the phone/in person Constantly (0-67%)
  • Typing on a computer keyboard Constantly (0-67%)
  • Moderate Standing/walking (33-67%)
  • Ability to occasionally lift 20 - 30 lbs. (0-33%)
  • Ability to wear PPE on regular basis (67-100%)


The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individual so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under his/her supervision.


EOE M/F/Disability/Vet


Andelyn Biosciences is currently operating under Executive Order 14042 that requires that employees of federal contractors and its affiliates be vaccinated against COVID-19, with some limited exemptions under the law.  As Andelyn is both an affiliate and will be a federal contractor, proof of vaccination status will be required prior to first date of employment.  Religious and medical exemptions may be considered depending upon the specific job duties and in accordance with applicable federal guidelines.


 


 

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