Nkarta Therapeutics is a publicly traded (Nkarta NKTX symbol), South San Francisco headquartered, early-stage biopharmaceutical company focused on the discovery, development and commercialization of allogeneic, off-the-shelf engineered natural killer, or NK, cell therapies to treat cancer.

 

Reports to                  Associate Director, Quality Control

Location                     South San Francisco, CA

 

Position Summary

Nkarta is currently offering a unique opportunity for a highly-motivated QC Professional to join our team with expertise in QC and cell-based assays preferably with cell therapy experience.  Initial responsibilities will include qualification of the new QC laboratory and phase-appropriate method qualification.  The qualified candidate will coordinate closely with internal and external partners in a cross-disciplinary team of immunologists, engineers, and clinicians to develop and implement testing processes that embody best practices in cell therapy manufacturing.

 

Key Responsibilities

·      Write and implement QC procedures and practices

·      Perform instrument and method qualification (method qualification will be phase appropriate)

·      Perform product testing (most assays are cell-based (e.g., flow cytometry, PCR, cellular imaging, etc.)

·      Investigate out of specifications and deviations appropriately

·      Initiate change controls

·      Write and execute validation protocols and reports

·      Participation in risk assessments as required.

 

Position Requirements

  • Excellent communication skills, both written and oral, and high degree of organization in terms of goal setting and achieving.
  • Independence and creative problem-solving abilities; comfort working in the fluid structure of start-up biotech.  Integrity, confidence, passion and collaborative spirit will be highly valued.
  • Previous experience in QC and cell-based assays is required.  Experience with cell therapy is preferred.
  • Experience with setting up and developing an entire QC lab is a plus.
  • Willingness to travel up to 10%.
  • Embodies the Nkarta culture of empowerment, diversity, and inclusion.

 

 

Education / Background

·     Bachelor’s degree in Biology, Chemistry, Life Science, or Engineering is required; advanced degree is preferred.

·     2-10 years of biopharmaceutical industry experience.

 

Work Environment / Physical Demands

This position requires the ability to occasionally lift and/or move up to 25 pounds. Specific vision abilities for this job include close vision, depth perception, and ability to adjust focus. The common requirements of an office environment (computers, computer screens, workstations, etc.) apply when not working in or around the laboratory environment. Car and airplane travel are a requirement of this role.

 

About Nkarta

 

Founded in 2015 at the birthplace of biotechnology, our development pipeline of engineered NK cell therapy candidates includes two co-lead clinical programs, NKX101 and NKX019. Clinical trials for 101 are in process; 019 will begin in H2 2021. Nkarta recently announced a collaboration with CRISPR Therapeutics, a world leader in gene-based medicines, for the development and commercialization of up to three new cell therapy candidates and access to clinically validated CRISPR/Cas9 genome engineering.

 

Complementing our broad research and development capabilities, Nkarta has also built an extensive cell therapy manufacturing operation.  We have a 2,700-square foot clinical good manufacturing practice, or cGMP, facility on-site at our primary corporate location in South San Francisco, California. We plan to start in-house manufacturing of NKX019 in 2021 and NKX101 in 2022. We are also currently designing a separate, larger cGMP facility, to supply our anticipated pivotal clinical trial and commercial needs.

 

Working at Nkarta

 

The 130+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas in which we’re working, here are real anonymous comments of why people think Nkarta is a great place to work.

 

·                     “People are always open to ideas. This company provides a safe place for its employees (covid testing, etc.)”

·                     “Exceptionally talented, committed, *kind* & supportive team”

·                     “The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique.”

·                    “Not to sound corny, but the emphasis on people as a valuable resource is something I  recognize doesn't often exist elsewhere, and it's here in ample supply, which is great.”

·                     “It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood.”

·                     “We have a very diverse team with executives that are friendly and accessible.”

·                    “Smart and dedicated colleagues. Mission to make a difference in patients lives. Empower us with tools needed to succeed.  Open and transparent culture. Transparent leadership. Handling of covid and running the company was done very well.”

 

To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company’s website at https://www.nkartatx.com