Nkarta Therapeutics is a publicly traded (Nkarta NKTX symbol), South San Francisco headquartered, early-stage biopharmaceutical company focused on the discovery, development and commercialization of allogeneic, off-the-shelf engineered natural killer, or NK, cell therapies to treat cancer.


Location                     South San Francisco, CA

Reports to                  Principal Scientist, Pharmacology


Position summary

This role adds to our growing pre-clinical team to support the development of Nkarta’s NK cell therapy pipeline.

Key Responsibilities:

·    Independently design study plans and conduct high quality in vivo studies

·    Develop and validate new mouse tumor models to evaluate the efficacy of novel Nkarta products

·  Establish and characterize innovative in vivo methods to study engineered cell therapies

·  Conducts pharmacological evaluation of test agents in subcutaneous, systemic and orthotopic in vivo oncology models.

· Supports ex vivo sample analysis to profile test agents in vivo activity and mechanism of action

·    Analyze, interpret, and communicate scientific data to team members in a timely manner

·    Present scientific findings at team and staff meetings

Position Requirements

· Extensive and diverse hands-on experience with various rodent models of oncology and immunological pharmacodynamic responses

·       excellent skills in animal dosing (i.v., s.c. required) and tissue collection.


Ability to independently design, coordinate, and execute in vivo and ex vivo studies.

·       Experience with various analytical methods (Flow cytometry, Elisa, etc.)

·       Timely production of quality data and excellent record keeping.

·       Dedication to working in a team-oriented environment to contribute to shared project and organizational goals.

·      Ability to multi-task in a fast-paced drug discovery environment with enthusiasm and persistence regardless of challenges.

·       Excellent communication skills with ability to effectively communicate both oral and written scientific results and conclusions to peers, supervisor and department teams.

·       Embodies the Nkarta culture of empowerment, diversity, and inclusion.


Education / Background

·     BS or MS degree in biological science, animal science, cancer biology or a related discipline with 5+ (associate scientist level) or at least 7+ years (scientist I level) of hands-on in vivo experience or PhD with 0-2 years of relevant experience (scientist I level).


 Work Environment / Physical Demands

This position requires the ability to occasionally lift and/or move up to 25 pounds. Specific vision abilities for this job include close vision, depth perception and ability to adjust focus and the ability to work in and around common laboratory equipment. Normal lab PPE including eye protection as well as masking (Covid mitigation) required. The regular requirements of an office environment (computers, computer screens, workstations, etc.) apply when not working in or around a laboratory environment. 


About Nkarta


Founded in 2015 at the birthplace of biotechnology, our development pipeline of engineered NK cell therapy candidates includes two co-lead clinical programs, NKX101 and NKX019. Clinical trials for 101 are in process; 019 will begin in H2 2021. Nkarta recently announced a collaboration with CRISPR Therapeutics, a world leader in gene-based medicines, for the development and commercialization of up to three new cell therapy candidates and access to clinically validated CRISPR/Cas9 genome engineering.


Complementing our broad research and development capabilities, Nkarta has also built an extensive cell therapy manufacturing operation.  We have a 2,700-square foot clinical good manufacturing practice, or cGMP, facility on-site at our primary corporate location in South San Francisco, California. We plan to start in-house manufacturing of NKX019 in 2021 and NKX101 in 2022. We are also currently designing a separate, larger cGMP facility, to supply our anticipated pivotal clinical trial and commercial needs.



Working at Nkarta


The 130+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas in which we’re working, here are real anonymous comments of why people think Nkarta is a great place to work.

·              “People are always open to ideas. This company provides a safe place for its employees (covid testing, etc.)”

·              “Exceptionally talented, committed, *kind* & supportive team”

·              “The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique.”

·             “Not to sound corny, but the emphasis on people as a valuable resource is something I  recognize doesn't often exist elsewhere, and it's here in ample supply, which is great.”

·              “It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood.”

·              “We have a very diverse team with executives that are friendly and accessible.”

·              “Smart and dedicated colleagues. Mission to make a difference in patients lives. Empower us with tools needed to succeed.  Open and transparent culture. Transparent leadership. Handling of covid and running the company was done very well.”

To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company’s website at https://www.nkartatx.com