Nkarta Therapeutics is a publicly traded (Nkarta NKTX symbol), South San Francisco headquartered, early-stage biopharmaceutical company focused on the discovery, development and commercialization of allogeneic, off-the-shelf engineered natural killer, or NK, cell therapies to treat cancer.



Position Title              Senior Scientist/Scientist, Cell Therapy Development

Location                      South San Francisco, CA

Reports to                   Staff Scientist


Position Summary

This key role adds to the build out and further development of our growing discovery research team for Nkarta’s NK products. Works both independently with team members to advance the company’s growing pipeline.


Key Responsibilities

·     Helps lead Nkarta’s efforts to develop next generation CAR cellular therapies.

·     Optimizes CAR designs to enhance NK cell functions

·     Works independently on experimental designs, executes and troubleshoots in vitro and in vivo experiments

·     Collaborates with Nkarta’s in vivo group with design and oversees in vivo CAR NK experiments

·     Works collaboratively and effectively across teams.


Position Requirements

·     Ability to work successfully in a fast-pacedp environment.

·     Thorough, demonstrated understanding of CAR cell therapy

·     Proficient in immune phenotyping of cultured immune cells using multi-color FACs and FlowJo-based data analysis.

·     Ability to work on complex problems where analysis requires an evaluation of multiple factors.

·     Able to exercise independent judgment performing experimental methods, techniques, evaluation criteria for obtaining results, and data analysis.

·     Strong verbal and written communication skills for documentation of data, drafting of technical reports, and communication of progress to supervisor and project teams

·     The ability multi-task within a fast-paced team environment with a high degree of self-motivation and organization

·       Embodies the company culture of empowerment, diversity, and inclusion.



·     In-depth experience with in vitro cellular/immune/tumor biology.

·     A working knowledge of engineering and assaying both in vitro and in vivo in cell therapy


Education / Background

·      Ph.D. in immunology, cancer biology, gene therapy or related field

·      2 or more years of relevant experience


About Nkarta

Founded in 2015 at the birthplace of biotechnology, our development pipeline of engineered NK cell therapy candidates includes two co-lead clinical programs, NKX101 and NKX019. Clinical trials for 101 are in process; 019 will begin in H2 2021. Nkarta recently announced a collaboration with CRISPR Therapeutics, a world leader in gene-based medicines, for the development and commercialization of up to three new cell therapy candidates and access to clinically validated CRISPR/Cas9 genome engineering.

Complementing our broad research and development capabilities, Nkarta has also built an extensive cell therapy manufacturing operation.  We have a 2,700-square foot clinical good manufacturing practice, or cGMP, facility on-site at our primary corporate location in South San Francisco, California. We plan to start in-house manufacturing of NKX019 in 2021 and NKX101 in 2022. We are also currently designing a separate, larger cGMP facility, to supply our anticipated pivotal clinical trial and commercial needs.


Working at Nkarta

The 130+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas in which we’re working, here are real anonymous comments of why people think Nkarta is a great place to work.

·       “People are always open to ideas. This company provides a safe place for its employees (covid testing, etc.)”

·       “Exceptionally talented, committed, *kind* & supportive team”

·       “The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique.”

·       “Not to sound corny, but the emphasis on people as a valuable resource is something I  recognize doesn't often exist elsewhere, and it's here in ample supply, which is great.”

·       “It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood.”

·       “We have a very diverse team with executives that are friendly and accessible.”

·       “Smart and dedicated colleagues. Mission to make a difference in patients lives. Empower us with tools needed to succeed.  Open and transparent culture. Transparent leadership. Handling of covid and running the company was done very well.”


To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company’s website at https://www.nkartatx.com