The key responsibilities of the senior scientist include end-to-end ownership of experiment plans and designs to support viral vector downstream process development. The candidate will analyze and present data at cross-functional and process development team meetings. The senior scientist will be responsible for technical leadership during internal and external technological transfers.


  • Laboratory leadership and providing direction to support staff during studies
  • Take a lead role in developing experimental plans to deliver a platform technology toolbox for clinical candidates
  • Perform and analyze Design of Experiment (DOE) studies to develop or optimize processes to ensure a phase-appropriate, consistent, high-yielding, high-purity, and scalable downstream purification.
  • Develop and demonstrate a robust, high purity/yield, and scalable purification process for clinical-stage Viral Vectors.
  • Compile and present data and conclusion to management
  • Serve as technical lead for internal and external tech transfers
  • Support downstream external development and manufacturing
  • Support upstream process development as required
  • Mentor and teach new staff
  • Author technical reports
  • Perform analytical assays


  • Ph.D. with 2-4-years of experience or MS with more than 8 years of relevant industrial experience in Biochemistry, Microbiology, Biology, Chemical Engineering, Biochemical Engineering, or a closely related field.
  • Solid and hands-on downstream purification experience is required. Downstream process development of viral vectors using viral filtration, AKTA chromatography systems, tangential flow filtration, and centrifugation required
  • Technical transfer experience preferred
  • Mammalian cell culture experience preferred
  • Ability to adapt and perform in a fast-paced and changing environment
  • Experience using design software (JMP, MatLab, etc.) preferred

Spirovant is committed to fostering a diverse, inclusive environment and is proud to be an equal opportunity employer.

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