Spirovant is a gene therapy leader focused on changing the course of cystic fibrosis and other respiratory diseases. Our gene therapy technologies are using adeno-associated virus (AAV) and lentivirus vectors designed to overcome the historical barriers that have prevented effective genetic treatments for conditions such as cystic fibrosis. We are a rapidly growing company located in the biotech heart of University City, Philadelphia.

To support our continued expansion and enable our future success, Spirovant is looking for a Research Associate, Respiratory Gene Therapy, with the following Responsibilities and Requirements:

Responsibilities:

• Execute molecular and biological research to optimize AAV and lentivirus vectors to enhance the efficiency of airway cell targeting and transduction.
• Assess expression of various transgene products using established methodologies.
• Technical experience with molecular biology (PCR, ddPCR, RNA tissue extraction), biochemical analysis (ELISA, FACS), cell culture, cell transfection/infection and immune-histological methods.
• Experience in AAV and/or lentivirus vector packaging, preparation, purification, analysis and viral titer assays.
• Experience with primary airway cell cultures, differentiation and phenotyping is preferred.
• Experience with confocal microscopy is a plus.
• Generate, manage, and maintain data in a highly organized manner.
• Maintain compliance with facility mandated chemical inventory and safety requirements.
• Generate, analyze, and maintain data produced from a wide variety of laboratory techniques and analytical methodologies.
• Help prepare technical reports, papers, tech transfer documents, presentations and SOPs for regulatory or for use in further research activities as needed.

Requirements:

• Bachelor’s degree in relevant biological sciences (i.e. molecular biology, biochemistry, pharmacology, or a related field), and a minimum of 2 years laboratory experience in AAV and/or lentivirus vector design and cloning.
• Experience in respiratory disease and/or immunology.
• Collaborative and responsive to scientific and technical needs.
• Proficiency in using Electronic Laboratory Notebooks.
• Excellent verbal and written communication skills.
• The candidate will be a high-level individual contributor who is self-motivated and integrates effectively into the team, enhancing the team’s overall efficiency and productivity.

Spirovant is committed to fostering a diverse, inclusive environment and is proud to be an equal opportunity employer.