We are seeking a candidate who has a broad understanding of the pathophysiological mechanisms underlying respiratory diseases. This candidate is expected to demonstrate a passion for innovative scientific research leading to the discovery and development of novel gene therapies with particular emphasis on translational approaches to clinical proof of concept and benefit to patients. Expertise in the biology of human lung cell types, including, but not limited to, various epithelial, glandular, progenitor and stem cell types, and their malfunctioning in respiratory diseases is required. The successful candidate is a technical expert in culturing, differentiating and manipulating primary lung cells in vitro.
The candidate will lead a team of scientists with the primary goal to discover novel gene therapies for respiratory diseases in close collaboration with AAV and Lentivirus technology research. The candidate will be responsible for implementing the research strategy, as well as providing scientific leadership and direction for junior scientists. The candidate will inspire, develop, and critically evaluate research that results in novel discoveries and new therapies. The ability to generate and lead numerous parallel discovery projects, while focusing on promising avenues for novel insights into human disease and the opportunities for novel gene therapies, is essential.
Strong leadership skills are required. Previous industry experience with a record of effective project leadership is a plus. The successful candidate should be able to work productively in a matrix team environment. Excellent written, oral, presentation and interpersonal skills are important.
A summary of the responsibilities includes:
Directs lung biology research in relevant in vitro cellular assay systems and demonstrates proof of mechanism and benefit to patients for the discovery of new gene therapies.
Motivates and inspires a group of talented scientists.
Provides leadership, supervision, scientific and technical mentoring and support to research scientist and research associate direct reports.
Collaborates with R&D and Nonclinical Development leadership to ensure that Research focus areas and prioritization are aligned with R&D and company objectives.
Communicates strategies, data, priorities and results across the organization.
Initiate, maintain and manage external research relationships with academic partners.
Provide leadership and support to research scientists.
Collaborate with R&D leadership to ensure gene therapy products meet therapeutic target needs.
Identify, support and manage talent; provide real-time feedback to direct reports for performance management and career development.
Regularly communicate results to project teams and senior leadership; prepare presentations, reports, patent filings and external communications as required.
At Spirovant, the successful candidate will be a highly creative leader and problem solver, who thrives in a “get it done” type of environment. (S)he will have the following mix of personal and professional characteristics:
PhD in cell biology, molecular biology, biochemistry, or a related discipline.
Lung biology research experience required, cystic fibrosis research experience highly desirable.
8+ years of experience post PhD, with preferably at least 5 years of experience in an industry setting
Demonstrated record of success with strong publication record.
Strong experience with cell biology techniques molecular biology techniques, including gene therapy technologies, molecular cloning, protein expression and purification and mammalian cell culture.
Self-starter and strategic thinker with a demonstrated ability to drive innovation.
Leading a project to completion or championing a technology initiative is preferred.
Clear communication skills in writing and presentation is required.
Team oriented, highly motivated, execution focused with strong work ethic, ability to thrive in an entrepreneurial and multidisciplinary environment.
Flexible, collaborative and responsive to scientific, technical and business opportunities and needs.