Senior Scientist – Principal Scientist  Protein Sciences, Biophysical/Analytical Characterizations

April 2024

Department:  Technology


Work Location:  Corporate Headquarters (South San Francisco)


Position Summary

TCG Labs-Soleil is seeking an experienced, passionate, and self-motivated scientist to join our growing multidisciplinary Protein Sciences group within the biologics Technology team.  This critical role will independently design, execute, and interpret analytical and biophysical characterizations in support of a diverse protein and antibody focused pre-clinical therapeutic pipeline. This candidate will work closely with scientists across research and early development.



  • Design, develop, and implement analytical methods for the characterization of diverse biologics with an emphasis on LC-MS and biophysical characterization to drive discovery programs through the research pipeline.
  • Establish and validate robust biophysical assays to characterize therapeutic biologics (monoclonal antibodies, bispecific antibodies, fusion proteins, etc.)
  • Independently design and execute experiments, make detailed observations, analyze and interpret data, and deliver results in a concise and timely manner to the team.
  • Establish and validate antibody-based functional assays and characterization processes.
  • Manage CROs and external collaborations on analytical development.
  • Prepare precise technical summaries, protocols and maintenance of appropriate documentation.
  • Contribute to program team discussions as a functional lead to support program progression.
  • This is a full-time and lab-based position.



  • Ph.D. or equivalent in a related discipline (e.g. molecular biology, biochemistry, biophysics, analytical chemistry) with 5-8+ years’ experience in protein and antibody characterization in industry setting, preferably startup or biotechnology companies.
  • Expert in biophysical techniques including but not limited to HPLC, CE, SPR, DSF, DSC, SEC-MALS, and LC-MS analysis.
  • Solid understanding of protein analytical principles and methodologies is required.
  • Hands-on experience with protein PTMs characterization and solid understanding of attributes of protein therapeutic drug candidate molecules is required.
  • Hands-on experience with protein/antibody biophysical assays such as SPR binding kinetics and antibody binning is required.
  • Hands-on experience with developability studies on antibody therapeutics including bispecific and antibody-drug-conjugates is highly desired.
  • Hands-on experience with membrane proteins is desired.
  • Prior experience with IND filing is desired.
  • Strong attention to details in experimental setup, capability to multitask and run multiple experiments in parallel without compromising quality.
  • Experience with protein purification is a plus.
  • Excellent oral presentation and written communication skills.
  • Strong team working skills, flexible and able to adapt in new scientific areas and learn new techniques quickly.
  • Ability to prioritize and work in a fast-paced and diverse environment.
  • Demonstrated scientific publication work.


Company Overview

TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

For more details, visit and follow us on LinkedIn


EEO Statement

TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to 


Benefits and Compensation 

TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.


The anticipated salary range for fully qualified candidates applying for this role will be $122,500 - $250,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.


Staffing Agencies

TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees.  Inquiries must be sent to with the Subject Heading:  Staffing Agency Request.