Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit and follow us on LinkedIn and X (Twitter). 


Uniquely Differentiated. Rapid. Elegant. 

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work® 


Position Description: 

Reporting to the Associate Principal Scientist, Analytical Development, this experienced and motivated Associate Scientist / Senior Research Associate will play a key role in supporting activities of routine analytical testing and method qualification for CARTA and CAART pre-clinical and clinical programs.  This position requires a skilled scientist with a background in biology and experience in QC testing for lentiviral vector and CAR T cells and method qualification.


Job Responsibilities:

  • Perform quality control testing to evaluate lentiviral vectors, CAR-T / CAAR-T cells and stability samples generated by internal groups and external partners.
  • Assist to develop analytical methods for the characterization and release of lentiviral vectors and CAR-T / CAAR-T cells.
  • Assist to Identify and implement opportunities for analytical method improvement and participate optimization of existing analytical methods to enhance sensitivity and efficiency.
  • Perform method qualification studies in accordance with regulatory guidelines.
  • Perform general lab and equipment maintenance duties.
  • Participate in technical troubleshooting and problem investigation.
  • Prepare, evaluate, and present data internally to cross functional teams.
  • Prepare detailed and accurate documentation of experimental procedures, results, and conclusions.
  • Stay current with advances in analytical techniques and industry trends.



  • Bachelor’s or master’s degree in biology or closely related discipline, and with 1-3 years of experience.
  • Proficient in aseptic technique for cell culture and cell-based assays.
  • Experience in analytic techniques, including flow cytometry, qPCR/dPCR, or ELISA etc.
  • Flexible to support various analytical activities and to learn new techniques outside of existing field of expertise.
  • Experience with quality control programs for lentiviral vector and CAR-T product preferred.
  • Ability to work collaboratively in a fast-paced environment.
  • Highly organized and strong written and verbal communication skills.
  • Strong laboratory documentation practice with high scientific integrity.
  • Strong team orientation and passion for continuous self-development. 
  • Experience in the biotech industry or in a startup industrial setting is preferred. 

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression. 


For more information, please visit 

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.  


Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. 


Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation. 


And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm. 

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