Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit and follow us on LinkedIn and X (Twitter).


Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®


About the Position

At Cabaletta Bio, we are focused on delivering cellular therapies to treat autoimmune disease indications.  The translational medicine group works closely with both clinical operations and computer biology teams to ensure that data from clinical stage assets is accurate and of the highest standards.  Reporting to the Associate Principal Scientist, Translational Medicine, we are seeking an experienced, motivated, detail-oriented, and highly skilled Scientist or Sr. Scientist within our translational team.

Under scientific and technical supervision, the individual will design, optimize, and perform assays that characterize Cabaletta’s clinical-stage candidates.  Specific responsibilities include the implementation and execution of multi-parameter flow cytometry and cell-based assays intended to evaluate pre- and post- characteristics of the clinical assets.  Additionally, multiplex assays will be used on serum samples to measure immune-related factors for changes in disease signatures. As part of the Translational Medicine team, the individual must be able to perform qualified assays on clinical trial participant materials, adhering to internal compliance standards.  The individual may assist the Associate Principal Scientist in devising and implementing strategies for ad hoc investigations that arise throughout candidate testing. The position allows for collaboration with additional Cabaletta research teams, including preclinical and molecular biology, cellular immunology, and next-gen cell therapy development.



  • Design and/or perform high-dimensional flow cytometry assays for the analysis of clinical samples.
  • Design and/or perform cell-based assays, including cell cytotoxicity and ELISPOT.
  • Qualify assays and generate high-quality SOPs while working closely with quality assurance (QA) team members. 
  • Manage multiple internal projects for the Translational team with potential support across functional teams, as well as involvement in collaborations with external vendors.
  • Actively contribute to process improvements and the implementation of new technologies.
  • Perform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies and SOPs.
  • Maintain accurate and well-organized records and electronic laboratory notebook.
  • Support clinical sample management and tracking of incoming patient samples.
  • Maintain detailed oriented notes and records for clinical sample lifecycle (receipt, usage, etc.).



  • Minimum PhD degree in Immunology or Biology (or related field) or MS with 2-3 years related experience.
  • Strong background in Immunology, B and T cell biology,  
  • General lab skills, including aseptic techniques and human tissue handling.
  • Expertise in flow cytometry high-dimensional panel design and implementation.
  • Must be highly organized and able to work independently.
  • Must be able to clearly communicate in writing.
  • Encompass a desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise. 
  • Strong team orientation and passion for continuous self-development.
  • Strong time management skills and ability to prioritize work across projects according to company objectives.


Preferred Skills

  • Previous experience with GLP/GCP work and handling of clinical samples is preferred.
  • Clinical sample inventory management/LIMS experience.
  • Experience with ELISPOT and Meso-scale Discovery electrochemiluminescence assays.
  • Experience in cytotoxicity assays (such as IncuCyte, xCELLigence, 51Cr or luciferase-based assays).
  • Translational experience in an industry setting.
  • Comfortable working in fast paced environment.
  • Strong team orientation and passion for continuous self-development.
  • Experience in the biotech industry or in a startup industrial setting is preferred.


Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

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