Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit and follow us on LinkedIn and X (Twitter).

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work®

About the Position

Reporting to the Director IT and Data Sciences, we are seeking a Senior IT Systems Administrator to be responsible for the implementation, support, and continuous improvement of the IT infrastructure and collaboration systems to ensure they exceed the needs of our internal customers.  The individual will support systems with stakeholders across all departments, and be responsible for maintaining compliance with cybersecurity and regulatory requirements. This is a hands-on role that requires deep experience with the M365 stack, AWS Hybrid cloud, and Linux/Windows servers and workstations.

This role is located in Center City, Philadelphia. We are a hybrid work environment, and the expectation is that this role will be in the office 2+ days per week (as required), with the remainder of the week remote.


  • Responsible for design, implementation, configuration, and support of servers, network devices and firewalls in collaboration with IT and business teams.
  • Operational activities (e.g., end-user support, break-fix, sustaining compliance) of IT systems including servers, network devices and firewalls. This includes monitoring, patch management, system backup/recovery, system administration, troubleshooting, change control, deviation and CAPA management, and issue resolution.
  • Assist in troubleshooting Tier 2/3 escalations through communication with end users and service providers.
  • Administer and support core Linux, Microsoft, Cisco, and VMware technologies.
  • Maintain and support AWS hybrid cloud environment: EC2, VPC, ELB, RDS, S3.
  • Maintain and support M365 systems: Exchange, SharePoint, Teams – Including Microsoft Entra ID.
  • Maintain BC/DR systems to comply with data retention requirements and perform periodic testing.
  • Ensure IT systems maintain compliance with cybersecurity and regulatory standards.
  • Create and maintain comprehensive documentation of IT Systems (such as: SOPs, User Guides, Training Materials, Test Plans, Validation Documents).
  • Assist staff and partners in understanding and using technology, provides presentations and training as required.
  • Manage SDLC of IT systems as required, including: On-Premise, IaaS, PaaS, SaaS
  • Collaborate with the Quality and Compliance department to support the validation process through SDLC activities; develop and/or execute test scripts as required.
  • Support data integrity processes for IT systems and Lab Workstations.
  • Other assignments and projects as required.


  • Bachelor’s degree with 5+ years of working experience as a System Administrator or similar role in biotech, pharmaceutical, or life sciences industries.
  • Experience with LAN/WAN networks, including wireless and firewall management.
  • Experience with Operational Technology network segmentation is a plus.
  • Strong experience in AWS: EC2, VPC, ELB, RDS, S3.
  • Strong experience with Windows Server 2016/2019/2022 and RHeL 7/8/9 server operating systems.
  • Experience maintaining M365 applications: Exchange, SharePoint, Teams, Entra ID – including SSO, SAML, OIDC configuration.
  • Solid understanding of Active Directory, GPO’s, Windows file and folder permissions.
  • Experience with backup and recovery platforms.
  • Excellent project management, communication, and problem-solving abilities.
  • Strong curiosity and the ability to learn quickly and adapt to a fast-changing environment.
  • Strong background in client support and demonstrated ability to work with clients who have a wide variance in IT and computing skill levels.
  • Strong team orientation and passion for continuous self-development
  • Comfortable in a fast-paced small company environment.
  • Experience in a startup industrial setting is preferred. 

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.