Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit and follow us on LinkedIn and X (Twitter).

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

About the Position

Reporting to the Director IT and Data Sciences, we are seeking an IT Laboratory Systems Administrator/Analyst to be responsible for leading the implementation, development, customization, and continuous improvement of laboratory information systems to ensure they meet the specific needs of our laboratory operations. The individual will work closely with Laboratory Operations, Computational Biology, and other stakeholders to enhance the efficiency and functionality of multiple laboratory systems. This is a hands-on role that requires design/coding with application development and support experience and integration/functional support of laboratory endpoints.

This role is located in Center City, Philadelphia. We are a hybrid work environment, and the expectation is that this role will be in the office 2+ days per week (as required), with the remainder of the week remote. 


  • Responsible for design, implementation, customization, configuration, and support of laboratory information systems to align with laboratory workflows, data requirements, and reporting needs.
  • Design, develop and maintain custom modules, data entry UI, and scripts to automate tasks and integrate laboratory instruments and information management systems.
  • Provide technical guidance and mentorship to CRO partners, System Owners, laboratory staff, troubleshoot issues and address user inquiries related to application functionality.
  • Ensure that the lab systems comply with industry regulations, standards, and data security protocols.
  • Collaborate with business teams to create and maintain comprehensive documentation for customizations, configurations, mapping workflows, integration system testing, user acceptance testing, SOPs, User Guides, Training Materials, Test Plans, and Validation Documents, while also driving continuous improvement and implementing system enhancements for operational efficiencies and cost reductions.
  • Provide support to staff and CRO partners by conducting presentations, training sessions, and sharing expertise through documentation, aiming to enhance their understanding and utilization of technology and lab systems.
  • Oversee the operational activities and SDLC management of critical systems such as LIMS, ELN, LES, QMS, and instrument workstation applications, encompassing end-user support, compliance sustainability, monitoring, patch/release management, backup/recovery, administration, troubleshooting, change control, deviation/CAPA management, and issue resolution.
  • Collaborate with the QA/CSV department to support GxP validation processes, including IQ/OQ/PQ activities and test script development/execution, for both on-premises and enterprise systems deployments.
  • Drive and support data integrity processes for Central Lab Systems and Lab Workstations.
  • Perform role of IT owner and subject matter expert for Central Lab Systems, leading support, enhancements, and projects to leverage the platforms.
  • Administrator for multiple laboratory information systems, middleware and vendor systems responsible for, but not limited to; systems analysis, user account management, rules, test/order choice menus, barcode/printer management, report templates, statistical/ad hoc reports and other system-wide settings.
  • Data preparation, analysis and visualization utilizing programming and scripting using R, Python and SQL
  • Collaborate across departments to develop, deploy, and validate informatics pipelines and computer-based systems for manufacturing, laboratory, and quality management applications, emphasizing compliance and operational efficiency, while also partnering with project teams to address business needs through informatics solutions.
  • Collaborate closely with informatics, data engineering, and business teams to ensure alignment of data strategies with organizational goals.


  • Bachelor’s degree with 3+ years of working experience as a lead LIMS Developer or similar role in biotech, pharmaceutical, or life sciences industries.
  • Experience with IT projects supporting clinical drug development preferred.
  • Experience with Thermo Systems Sample Manager LIMS system is a plus.
  • Strong experience in software development using Python, Java, Bash, Perl, and SQL.
  • Experience in Windows and Linux endpoint operating systems.
  • Excellent project management communication, and problem-solving abilities.
  • Strong collaboration and influence skills to work effectively with cross-functional teams.
  • Strong curiosity and the ability to learn quickly and adapt to a fast-changing environment.
  • Strong background in client support and demonstrated ability to work with clients who have a wide variance in IT and computing skill levels.
  • Strong team orientation and passion for continuous self-development
  • Comfortable in a fast-paced small company environment.
  • Experience in the biotech industry or in a startup industrial setting is preferred.

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression. 

For more information, please visit 

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.  

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. 

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation. 

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.