Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on developing and launching targeted, potentially curative, cellular therapies for patients with autoimmune diseases. The CABA™ platform includes two strategies to treat and potentially cure many of the most common and challenging autoimmune diseases. The CARTA strategy, or Chimeric Antigen Receptor T cells for Autoimmunity, is designed to potentially reset the immune system by causing transient B cell depletion with early academic clinical data suggesting the potential of this strategy to transform treatment in patients with SLE and the possibility of cures in rheumatoid arthritis, myositis, and systemic sclerosis, among others. Our lead product candidate using the CARTA strategy is CABA-201, 4-1BB-containing CD19-CAR T designed specifically to treat patients with autoimmune diseases and which uses a CD-19 binder that has an encouraging clinical tolerability profile. The second strategy is Cabaletta Bio’s proprietary CAART, or chimeric autoantibody receptor T cells, strategy, which is designed to cause antigen-specific B cell depletion of well-defined, disease-causing B cells. Our lead product candidate developed using the CAART strategy is being evaluated in a clinical trial for patients with mucosal pemphigus vulgaris (mPV) and our second product candidate is expected to initiate a clinical trial later this year in muscle-specific tyrosine kinase (MuSK) myasthenia gravis. Cabaletta Bio’s headquarters are located in Philadelphia, PA. For more information, visit www.cabalettabio.com and follow us on LinkedIn and Twitter.

 

Uniquely Differentiated. Rapid. Elegant.

 At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

 We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

 

About the Position

 

Reporting to the Chief Medical Officer, this role includes facilitating the development of program strategy and driving the realization of that strategy through the development and management of executable plans. This includes planning and tracking progress for all internal and outsourced activities required to advance drug discovery projects forward. The ideal candidate has a strong scientific background and is experienced in drug discovery, vendor management and program / project management. This individual will demonstrate both attention to detail and the ability to think strategically.

 

Responsibilities:

• Lead program management activities for multiple programs in the development portfolio.
• Coordinate and drive cross-functional teams to efficiently advance development programs.
• Partner with the program team and functional leaders to create and maintain integrated drug development plans that define critical path activities, key milestones, cross-functional interdependencies, risks, and resource requirements.
• Proactively identify potential risks and challenges, escalate when appropriate, and seek resolution with input from program team members and senior leadership.
• Establish and foster collaborative relationships with key internal and external stakeholders, and functional subject matter experts, to drive effective decision-making and timely issue resolution.
• Partner with senior leadership to ensure strategic and operational alignment with program and company objectives.
• Organize and manage team meetings, including preparing agendas, taking minutes, and ensure post-meeting follow-through.
• Track progress and monitor health toward program goals and communicate program status to various stakeholders across the organization.
• Collaborate with internal stakeholders to continuously improve and implement best practices within program teams and across the organization.
• May lead additional ad hoc projects.

Qualifications:

• Bachelor's degree required; advanced science degree preferred (MS/Ph.D.)
• Minimum of 10 years of relevant biotech or pharmaceutical industry experience is required.
• 3 years minimum of hands-on experience in leading program management activities in early development is required.
• Must demonstrate good leadership and team building skills, ability to influence cross-functionally, work with different personalities and styles and maintain positive interpersonal relationships.
• Experience in drug development (preferably in one or more focus areas) across multiple phases (pre-clinical and/or clinical Phase 1-3).
• Proven track record of successful project management experience.
• Prior experience managing or working within cross-functional project teams with timeline management and budgetary responsibility.
• Strong knowledge of project management tools and software.
• Must be adept at working in a fluid environment and foster a strong collaborative spirit internally and externally.
• Strong written and oral communication skills as well as demonstrated organizational aptitude.
• Strong working knowledge of MS Project, Smartsheet, and timeline visualization software.

 

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

For more information, please visit https://www.cabalettabio.com/ or email careers@cabalettabio.com directly to apply. Please include your CV along with the title of the position for which you are applying.

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.