Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially-available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases.  The Company’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

 

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a new type of therapy, where patients’ own cells are used to fight disease.  We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company.  To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team.  In this way, we are not only working to improve the lives of patients, but of everyone involved.  #CabalettaCrew


About the Position

​Reporting to the Chief Scientific Officer, the Sr Manager/Associate Director Research Project Management will oversee planning, budgeting, integrating, tracking, and communicating cross-functional activities for Cabaletta Bio’s research programs, ranging in scope from discovery through to clinical development. This will include working with internal stakeholders, academic partners, and external vendors.


Responsibilities:

  • ​Creates and maintains all project timelines and is responsible for communicating changes to the approved plan.
  • Conducts activities to drive the execution of research projects and programs, and develops communication tools to support, including presentations and reports.
  • Establishes scopes of work, leads the delivery of project milestones in a timely fashion and within project management standards.
  • Leads cross-functional teams; plans and executes fully integrated program plans from Discovery to IND through to clinical trial initiation. 
  • Coordinates and tracks the status of cross-functional communication and integration activities.
  • As assigned, manages vendors to support research teams.
  • Facilitates problem-solving, contingency planning, and decision-making.
  • Supports, facilitates, and maintains effective project teams. 
  • Serves as a motivator, coach, and mentor to cross-functional team members, and proactively communicates enterprise company perspective and significant updates to teams.
  • Proactively communicates risks, critical path items and status, and feedback to the CSO and across senior leadership 
     

Required Qualifications

  • ​Minimum of a B.S./B.A. with 3-5 years’ project management experience working within the biotechnology/pharma industry
  • Ability to work independently and adapt to various personality types.
  • Excellent written and oral communication skills.
  • Ability to operate in a fast-paced environment
  • Strong team orientation, ability to work collaboratively, and passion for continuous self-development. 
  • Highly organized and efficient, with a curiosity to be part of cutting-edge science. 

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Preferred Qualifications

  • ​Background in cell or gene therapy discovery or pre-clinical development.
  • Experience in a start-up environment or wearing multiple hats within an organization.

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Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

For more information, please visit https://www.cabalettabio.com/ or email careers@cabalettabio.com directly to submit an application. Please include your CV along with the title of the position for which you are applying.

Our most important asset is our people and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

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