Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases.  The Company’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a new type of therapy, where patients’ own cells are used to fight disease.  We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company.    To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team.  In this way, we are not only working to improve the lives of patients, but of everyone involved. 

Cabaletta has a strong focus on people and values, and was rated in the top 20 companies to work for in Biotechnology and Pharmaceuticals by Fortune Magazine. https://fortune.com/best-workplaces-biotechnology-pharmaceuticals/2021/cabaletta-bio/

About the Position

Reporting to the Director, Translational Medicine, we are seeking an experienced, motivated, detail-oriented, and highly skilled Scientist or Sr. Scientist within our translational team.

Under scientific and technical supervision, the individual will perform various flow cytometry assays, cell-based assays and other molecular biology assays on clinical samples which will provide data and insight on the efficacy and characterization of Cabaletta’s clinical-stage candidates. Additionally, the individual will oversee cell line generation and maintenance to assist in the development of cell-based assays for the Translational team. The position allows for potential collaboration with additional areas within Cabaletta’s research team, including preclinical and molecular biology, immunology and cell therapy development.

Responsibilities will include:

·       Design and perform high-dimensional flow cytometry assays for the analysis of clinical samples.

·       Qualification of optimized assays and generation of high-quality SOPs.

·       Design and/or perform cell-based assays, including cytotoxicity assays.

·       Cell line generation using lentivirus technology for suspension cell lines.

·       Manage multiple internal projects for the Translational team with potential support provided to Analytical Development and Manufacturing Sciences, as well as involvement in collaborations with external vendors.

·       Actively contribute to process improvements and the implementation of new technologies.

·       Perform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies and SOPs.

·       Maintain accurate and well-organized records and electronic laboratory notebook.

·       Support clinical sample management and tracking of incoming patient samples.

·       Maintain detailed oriented notes and records for clinical sample lifecycle (receipt, usage, etc.).

Required Qualifications

·       Minimum PhD degree in Immunology, Biology or Bioengineering (or related field) with 2 + years of industry experience or post-doctoral training.

·       General lab skills, including aseptic techniques and human tissue handling

·       Prior experience with mammalian cell culture (aseptic techniques)

·       Experience and expertise in cell husbandry required, including maintaining cell culture, media preparation, generating and managing cell stocks and banking

·       Previous experience with GLP/GCP work and handling of clinical samples

·       Clinical sample inventory management experience

·       Expertise in flow cytometry high-dimensional panel design and implementation required

·       Must be highly organized and able to work independently

·       Must be able to clearly communicate in writing

·       Encompass a desire to be part of a growing organization that uses cutting-edge science

·       A high level of flexibility to support various other activities the ability to learn new techniques outside of existing field of expertise 

·       Strong team orientation and passion for continuous self-development

·       Experience in industry or in a startup industrial setting is preferred

Preferred Skills

·       Strong background in immunology preferred

·       Experience in cytotoxicity assays (such as IncuCyte, xCELLigence, 51Cr or luciferase-based assays)

·       Translational experience in industry setting

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

For more information, please visit https://www.cabalettabio.com/ or email careers@cabalettabio.com directly to submit an application. Please include your CV along with the title of the position for which you are applying.

Our most important asset is our people and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.