Associate Scientist, Translational Medicine

 

Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on developing and launching the first curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

 

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

 

Position Description:               

 

This role is located in Center City, Philadelphia and is primarily a lab-focused position.

Reporting to the Senior Scientist, Translational Medicine, the Associate Scientist, Translational Medicine will play a key role in generating and interpreting experimental data from clinical samples to advance understanding of the safety, biological activity, and therapeutic impact of Cabaletta’s clinical programs. This individual will design and execute laboratory studies that support translational research objectives, helping bridge clinical observations with underlying biological mechanisms.

 

The Associate Scientist will contribute to assay development, optimization, and execution to enable robust biomarker and translational analyses that inform clinical decision-making and regulatory strategy as the company progresses toward its first BLA. This role offers the opportunity to work cross-functionally with teams across clinical development, research, and technical operations, and to contribute broadly to Cabaletta’s mission of advancing innovative cell therapies for patients.

 

Responsibilities

 

  • Perform and support the development of laboratory assays on clinical (and potentially pre-clinical) samples to generate translational data that informs safety, biological activity, and therapeutic impact of rese-cel.
  • Manage clinical sample processing, accessioning, tracking, and lifecycle documentation with careful attention to metadata and data integrity.
  • Maintain accurate, GDP-compliant experimental records using electronic laboratory notebooks (ELN) and sample management systems.
  • Document all procedures and experimental parameters within our ELN and follow up with Quality Control/Assurance for review. Address and document any QA concerns and participate in root-cause assessments and CAPAs if necessary.
  • Contribute to assay development, qualification, and validation efforts and assist in the preparation of related SOPs.
  • Manage multiple internal projects and collaborate cross-functionally with Translational, Pre-clinical, and Analytical Sciences teams, as well as external partners.
  • Perform laboratory activities in accordance with GLP/cGLP standards, company safety policies, and SOPs, including general maintenance of laboratory space.
  • Other related duties, as assigned.

 

Qualifications:                                           

  • MS degree in Biology or Bioengineering (or related field) with 2 + years of experience, or Bachelor's degree with 4+ years of experience in the biotechnology industry required. Ph.D. level candidates will be considered as well.
  • Proficiency in flow cytometry and flow cytometry data analysis (using FlowJo or equivalent software) is required.
  • General lab skills, including aseptic techniques and human tissue handling required.
  • Previous experience with GLP/GCP (ALCOA+) and handling of clinical samples preferred.
  • Experience with MesoScale Discovery (MSD) VPLEX and UPLEX reagents and software is preferred.
  • Proficiency in GraphPad Prism, Microsoft Office software (i.e., Excel, PowerPoint) is preferred.
  • Must be highly organized and able to work independently in a fast-paced environment.
  • Must be able to clearly communicate in writing, must have a desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise.
  • Strong team orientation and passion for continuous self-development.
  • Experience in industry, specifically a startup setting, is preferred.

 

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit  https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

 

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

#LI-ONSITE