Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

We are seeking a passionate and driven Research Technician/Associate to join our team of immunologists driving the development of Selected-TIL therapies for the treatment of cancer. The successful candidate will provide support and assistance to senior researchers at our San Diego site using state-of-the-art instrumentation and following established laboratory standard operating procedures (SOPs).  In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution, and collaborate with team members across the research department.

The Responsibilities include but are not limited to the following:

• Molecular editing of immune cell populations and rapid expansion.

• Validation of editing using PCR and western blot or flow cytometry.

• Assessment of TIL phenotype using flow cytometry.

• Isolation of tumor and immune cells from patient samples.

• Assessment of TIL functionality using in vitro assays to measure cytotoxicity, expansion, and cytokine secretion.
• Support other team members by preparing reagents and materials.
• Generate quality data and study summary reports in a timely manner.
• Contribute to a team-centric culture that values transparency, innovation, integrity, and purpose.

Experience:

• B.S in Biology with previous experience in immunology is required.

• Must have experience with immune cell culture with excellent sterile technique.

• Experience with multi-parameter flow cytometry is preferred. 

• Experience with lentiviral and/or CRISPR-CAS9 techniques for editing and engineering immune cells is a plus.

• Experience with DNA isolation, PCR, and western blot analysis is a plus.

• Experience with tumor digestion and cell sorting is a plus.

• Strong work ethic, positive team-oriented attitude is a must.

The anticipated salary range for this role is $70,000 – $85,000.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.