Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.
Responsibilities include: working as part of a team at Turnstone’s Ottawa lab located at Carleton University, running established complex analytics to support product characterization, preclinical study sample testing, and analytical development.
The Research Technician will work with senior researchers to execute of cell-based virology and immunology assays following established laboratory standard operating procedures (SOPs) as well as to assist in preparation of data/figures in support of multiple projects. Additional responsibilities will include inventory management; organize freezers; routine maintenance; calibration and troubleshooting on laboratory equipment. We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
Experience & Qualifications:
· This role is best suited for an analyst early in their career, looking for a development opportunity, and with the following experience:
- MSc or BSc with relevant experience in an academic or industrial laboratory
- Preferred Experience with:
- Mammalian cell-culture and experience with viruses or other BSL-2 agents is preferrable
§ Preclinical mouse models including syngeneic and xenograft tumour models used to evaluate cancer immunotherapies and combination therapies
§ Recombinant DNA cloning
§ Protein analysis by gel electrophoresis and blotting
§ DNA analysis by qPCR
- Biochemical assays including ELISA and cell-based reporter assays
o Ability to multi-task
- Must have good analytical and problem-solving abilities
- Self-starter with a strong work ethic and attention to detail
- Knowledge and experience with standard software (e.g. Microsoft Office Suite, Graphpad Prism) Experience with electronic lab notebooks (ELN) would be an asset.
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.