Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
What’s in it for you?
Turnstone is seeking a Research Associate to join our team of immunologists driving the development of our growing pipeline of T cell and oncolytic virus immunotherapies. This is an exciting opportunity to work along side senior researchers and project teams to perform discovery and development research that will ultimately create new medicines for cancer patients.
Turnstone’s T Cell therapy technology is based around a powerful new Selected-TIL process that revolutionizes the generation of tumour targeted T cells for adoptive cell therapy. Your role will be to work with a team of immunologists and molecular biologists to invent and develop these next gen T cell products for preclinical and clinical evaluation. There will be additional opportunities to continually refine the technology and manufacturing processes for this class defining therapy. If you have experience with T cell manipulation, engineering and culture, then this opportunity may be just what you are looking for.
You will work along side senior researchers and supporting technical colleagues within project teams at our state of the art facilities in San Diego and participate in designing and executing cell-based human immunology studies following established laboratory standard operating procedures (SOPs). We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and grow your career right along with the company.
The Responsibilities include the following:
- Drive various aspects of in vitro and in vivo studies including but not limited to: designing and executing experiments, organizing teams, scheduling and managing complex multi-disciplinary experiments including data collection, analysis, and interpretation.
- Prepare data/figures to present to senior research staff
- Generate study reports in a timely manner
- Write and review SOPs
- Contribute to a team-centric culture that embraces scientific excellence, integrity, and urgency
How do you know if you’re the right fit?
- Degree in Immunology/Microbiology/Biochemistry (research primarily focused in immunology) with recent biotech or pharmaceutical industry experience preferred
- Extensive experience with immune assays including flow cytometry, ELISA, ELISPOT, immune cell culture and common molecular techniques.
- T-cell sorting / human experience
- Experience with T cell engineering is highly desirable
- Experience studying T cell metabolism and cell state is a plus
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.