Scientist or Engineer, Manufacturing Sciences


Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit or email


How do you know if you’re the right fit?


Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.


If you are interested in being a part of a growing Manufacturing Sciences team, then this role may be for you! As a Scientist/Engineer, Manfacturing Sciences, you will report to the Manufacturing Sciences lead, within the Bioprocess Development and Manfuacturing Sciences team. With responsibilities spanning our multi-virus platform, key duties as they relate to this role will include:


·       Act as technical lead to support the design and execution of complex biologic manufacturing processes.

·       Perform scale-up of unit operations to support pilot- and full-scale manufacturing processes of up to 500 L

·       Liase with the Process Development and Manufacturing Operations teams to translate process knowledge and critical process parameters to GMP manufacturing

·       Lead tech transfer of complex biologic processes between our external CDMO network spanning Canada, the United States, and Europe

·       Interface with our external CMO network to support the preparation and execution of engineering run campaigns

·       Perform data mining, analysis, and trending of quality attributes and batch run parameters

·       Support drafting and review of Master Batch Records, sampling plans, executed field copy documents, as well as regulatory documentation

·       Lead technical investigations into process deviations, excursions, and trends

·       Perform risk assessments across a variety of process, manufacturing, and equipment challenges

·       Oversee development of scaled-down models to support material generation, process characterization, and troubleshooting

·       Participate in equipment selection, procurement, and qualification processes


What’s in it for you?


In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you! 

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.


The Details


Turnstone Tech Ops is a virtual organization, where all of our wetbench work is executed third party CMO/CRO partners. We have offices in Ottawa, Canada and New York, USA – but considering the nature of our work and the global climate, this position can be stationed virtually – ideally within the Eastern time zone. This role is best suited for someone with the following:

·       5-7 years of overall experience within the biotech/pharmaceutical industry

·       Bachelors degree in Science / Engineering, with a Master’s or PhD considered an asset. Trained in one of the following fields: chemical engineering, biology, biochemistry, or virology

·       Experience working with biological processes (viruses preferred). In depth knowledge and experience in translating unit operations from lab-scale to GMP manufacturing scales of at least 500 L.

·       Experience in both upstream (e.g. cell culture, bioreactor operation, centrifugation) and downstream (e.g. chromatography, filtration, scale up) technologies.

·       In depth knowledge of current Good Manufacturing Practices. Experience with aseptic manufacturing processes (non-terminally sterilized drug substance) considered an asset

·       Enjoy data mining, trending, and graphing data for presentation within reports or at meetings. Strong statistical analysis capabilities considered an asset.

·       Excellent written communication skills to enable drafting of reports and risk assessments

·       Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment



Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

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