Who We Are

Ashvattha Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel hydroxyl dendrimer (HD) therapeutics (HDTs) to treat unmet medical needs in oncology, ophthalmology, and inflammatory diseases. We believe that HDTs will become the future of targeted therapeutics and unlock new levels of patient care.

The Role

We are seeking a leader with a strong background and experience in synthetic, medicinal or process chemistry for the development of hydroxyl dendrimer therapeutics (HDTs) for a wide range of therapeutic areas. The main responsibilities of this position are to remotely manage our existing early-stage research team in Baltimore and to establish a laboratory team in Redwood City to perform small scale and scale-up manufacturing of our HDTs. The candidate will also lead the efforts to design and optimize small molecule drugs for conjugation to the hydroxyl dendrimer platform creating a pipeline of HDTs. In addition, the candidate work with Manufacturing to transfer the manufacturing processes to Contract Manufacturing Organizations (CMOs) for GMP production to support clinical studies. The candidate will initially be both “hands on” in laboratory work as well as hire a team.

Key Deliverables

Set-up and operate new Redwood City laboratory (equipment/chemicals); Hire team to synthesize, purify and characterize HDTs; Produce sufficient HDT to support non-GLP toxicology of early stage development projects; In collaboration with senior management team, design, optimize and synthesize novel HDTs to specific targets

Core Skills & Experience Required

• Experience in synthesis of drug candidates and, preferably, polymer/dendrimer-drug conjugates, peptide/antibody conjugates, and/or other biomolecules

• Hands-on experience in analytical techniques, such as Liquid Chromatography (HPLC, UPLC), NMR, GPC, SEC-MALS and MALDI, and synthesis techniques including use of microwave reactors, rotary evaporators, freeze dryers, and tangential flow filtration systems.

• Optimization of lead candidate HDTs for scale-up and transfer to CMOs

• Ability to write technology transfer reports for CMOs

• Design, synthesize, and optimized drug-conjugates using structure activity relationships and/or crystal structure information