Who We Are
BlackThorn Therapeutics is a neurobehavioral health company developing targeted therapeutics, informed by a deep understanding of brain and behavior relationships, to significantly improve patient outcomes. The company has pioneered a proprietary computational psychiatry platform, which leverages bioinformatics, neuroinformatics and artificial intelligence technologies, with the goal of determining a patient's distinct neuroprint to inform the proper on-target treatment option for biologically defined patient subtypes. BlackThorn Therapeutics has completed a Phase 1 trial of BTRX-335140, a selective kappa opioid receptor antagonist, and is conducting IND-enabling studies for BTRX-323511, a selective vasopressin 1a receptor antagonist. Additionally, the company has a robust discovery effort pursuing novel therapeutic targets for neurobehavioral disorders.
The Position
We are seeking a highly motivated and detail-oriented in vitro pharmacologist with expertise in small molecule drug discovery to join a growing Biology team. The successful individual will independently develop and implement key cell-based assays to drive lead identification / optimization efforts for several research programs focused on the generation of novel therapeutics for the treatment of neurobehavioral disorders. The candidate will work in a multidisciplinary, collaborative environment with like-minded individuals. A successful candidate for this position will be detail-oriented and focused on team goals. The individual will be data-driven, adaptable and exhibit excellent collaborative and communication skills.
Responsibilities:
- Lead dedicated research efforts to support project teams
- Assist in the development of novel recombinant and neuronal cell-based assays to characterize small molecules
- Execute weekly screening using semi-automated systems
- Maintain mammalian recombinant cells, primary neurons, and iPSC-derived neuronal cell cultures
- Present data at department and project team meetings, contribute to publications and patents when necessary
- Maintain detailed record keeping of all technical manipulations and results using electronic notebook
- Proactively manage day-to-day laboratory duties
Who You Are
- Bachelor's / Master’s degree in a relevant scientific discipline with at least 5 years of experience in biotech or pharma environment
- Proficient in in vitro characterization of small molecules
- Competent with recombinant and neuronal cell culture, embryonic and/or induced pluripotent stem cell maintenance and differentiation
- Working knowledge of receptor pharmacology
- Experience with automated liquid handling systems and microplate-based cellular assays
- Experience with standard biochemical and molecular biology techniques such as PCR, Western blotting, and cloning methods