SCIENTIST – Cell Biology

Angiex, Inc. – LabCentral, Cambridge, MA 02139

Angiex is an innovative science-focused startup developing vascular-targeted biologic therapies for cancer and other diseases. Angiex’s lead program is an antibody-drug conjugate therapy for solid cancers. Angiex was launched out of Beth Israel Deaconess Medical Center and Harvard Medical School in 2016, is resident at LabCentral in Cambridge, and is backed by prestigious investors. Angiex founders have previously discovered VEGF-A, been recognized as the world’s leading experts in tumor blood vessel biology, developed new methods for per cell mRNA quantification, founded four companies, written a best-selling diet book, and won prizes for best salsa and pie recipes at LabCentral.

Job Description:

Angiex is seeking a talented, creative, self-motivated cell biologist to join in the investigation of novel cellular pathways in endothelial cells and tumor cells and the discovery and design of drugs specific to those pathways. The successful candidate will have extensive hands-on experience in cell biology, cell signaling assays, cell culture, imaging, and intracellular trafficking, and ability to perform in vivo mouse studies. Immunology or immuno-oncology expertise, or experience studying endothelial-leukocyte interactions, is a plus. The job offers exceptional opportunity for career development in one of Boston’s most exciting and promising biotech startups.

Responsibilities:

  • Develop and implement biochemical approaches and technologies to establish the activity, mechanism of action, trafficking, and metabolism of candidate therapeutics both in cells in vitro and mice in vivo.
  • Perform imaging studies using confocal microscopy, superresolution imaging, and electron microscopy.
  • Characterize the potency and signaling activity of candidate therapeutics in vitro and support selection of candidates for in vivo efficacy studies.
  • Develop and implement assays to evaluate molecular interaction networks in vitro and tissue specific cell signaling of candidate antibodies in vivo.
  • Cure cancer.

Requirements:

  • Ph.D. in biology, biochemistry, immunology, or a related discipline with substantial experience in wet-bench laboratory work and a strong record of accomplishment including a strong publication record.
  • Experience in cell biology, especially in intracellular trafficking, microtubule biology, gene expression regulation, cell cycle, and apoptosis.
  • Highly self-motivated, talented, and versatile candidate who can excel in a fast-paced and cooperative working environment, and who works with independent initiative yet in a team-oriented manner.
  • Capable of building strong, intimate, cooperative relationships with peers within the firm and partners outside the firm, relationships characterized by honesty, transparency, humility, and integrity.
  • Excellent oral and written communication skills.
  • Be talented enough to rapidly master tasks you've never done before, cooperative and communicative enough to make a great team even stronger, dedicated enough to accomplish in one week what others do in two, careful enough that experimental results are reliable, honest enough to say when they aren't, creative enough to wake up at 3 AM with ideas you can't wait to share, and cheerful enough to enjoy to the fullest the most exciting job you'll ever have.

Benefits: Angiex provides a highly competitive package of benefits including a broad selection of medical, dental, and vision plans, 401k plan, free parking in an adjacent garage or a free MBTA pass, and free membership at MIT Recreation.

Statement: Angiex is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.