Annexon Biosciences is a clinical stage biotechnology company
focused on developing novel inhibitors that are designed to block C1q and the
entire classical complement pathway. We are pioneers in targeting C1q, the
initiating molecule of the classical complement pathway. By stopping the start
of this pathway, our C1q inhibitors are designed to treat multiple
complement-mediated autoimmune, neurological and ophthalmic diseases of the
body, brain and eye. Annexon is headquartered in South San Francisco CA.
the leader of one of our therapeutic franchises,
the Project Team Leader will
provide strategic scientific, business and operational leadership and direction
of the R&D development and advancement of Annexon’s portfolio. In addition
to developing and driving a comprehensive lifecycle portfolio strategy, the Project
Team Leader will be responsible for leading a cross- functional leadership team
of both internal and external resources in all aspects of development pre-IND stage
through late stage development, ensuring consistent high quality output from
the team and achievement of program goals and objectives as well as drive
effective execution of such strategies by leading the cross functional team’s
engagement, integration, coordination and communication across functional
lines. Duties for this role also include
managing R&D partnerships, helping to build necessary infrastructure for
the R&D organization and working with the executive leadership to create an
environment that supports rapid and high quality decision making (both for the
portfolio and the organization) and to identify, evaluate and find solutions
for key issues facing the programs on an ongoing basis. The Project Team Leader
will report into the SVP, Portfolio Strategy & Operations.
- Partnering with internal and external stakeholders to drive the
development of a comprehensive strategic plan through registration and
pre-commercialization preparation, including goals, budget and risk assessment. Includes developing program vision, strategy,
scope/focus, milestones, risk assessment and management strategies, as well as
project investment requirements.
- Leading cross-functional Project Team focused on the development
of Annexon’s clinical candidates, from pre-IND through late stage clinical
development and NDA submission for multiple indications. Project Team shall include representation
from Research, Development, CMC, Regulatory, Quality, Commercial and Finance.
- Providing effective leadership and direction to the cross
functional Project Team, including scientific and operational oversight of
activities, budgeting and planning.
- Utilizing his/her understanding of disease biology, global drug
development and portfolio management to effectively lead the Project Team.
- Partnering with executive team to develop operating framework
within R&D, including with regard to the Project Team to clarify and
facilitate decision-making and escalation around strategic direction, resource
- Partnering with functional areas to identify and ensure adequate
resources for timely completion of goals and objectives. Ensuring team members understand program
objectives, specifications, deliverables, timelines, and tasks.
- Driving the development and implementation of lifecycle portfolio
strategy and follow-on drug candidates for multiple diseases.
- Managing and communicating program progress on a continual basis,
identifying both cross-program and cross-functional issues, resource issues,
timeline issues, and budget issues.
- Works on significant and unique issues where analysis of
situations or data requires an evaluation of intangibles
- Exercises independent judgment in methods, techniques and
evaluation of criteria for obtaining results
- Participates in corporate development of methods, techniques and
evaluation criteria for projects, programs and people
- Ensures budgets and schedules meet corporate requirements
- Creates formal networks involving coordination among groups. Regularly interacts with executives and/or
major internal and external customers
- Works on abstract problems across functional areas of the
- Identifies and evaluates fundamental issues for major function
areas through assessment of intangible variables. In-depth knowledge of
functional areas, business strategies and company goals.
- Interacts internally and externally with executive level
management requiring negotiation of matters to influence policymaking bodies
both internally and externally.
- Anticipates potential roadblocks and issues of conflict and
maintains open lines of communication in problem solving and resolving issues
- Leadership: Experience leading and motivating teams in a matrix
environment is required. Proven interpersonal skills with ability to influence,
resolve conflict and drive decisions among internal cross functional teams,
executive management, and external teams.
- Strategic Agility: Ability to develop and execute complex
- Collaboration/Relationship Management: Ability to effectively
collaborate in and across multiple functions,
and with internal and external stakeholders of various backgrounds and skill
sets. Skilled in establishing a collaborative and respectful environment.
- Influencing: demonstrated skills in persuading senior leadership
on strategy, initiative(s) implementation, and decision-making. Influences and
motivates others to achieve objectives.
- Decision Making: Strong decision-making skills taking multiple
perspectives into account and analytical skills are required; exercises sound
business judgment that has broad organizational impact.
- Communication: Excellent communication skills (both orally and
written) is critical to the success of the role.
- Business Excellence: Good at developing the processes necessary to
get things done, knows how to organize people and activities and knows what to
measure and how to measure. Demonstrated ability to interpret data into
Proven negotiation skills that effectively drive discussions and decisions to
desired end-results that have broad organizational impact.
successful candidate should have an advanced degree in life sciences or
medicine (PhD or MD) and/or commensurate experience. He/she will have at least 10 years of
industry experience in drug development, including experience in early phase
non-clinical and clinical drug development, regulatory knowledge and
pre-commercial market preparation.
scientific or industry experience within the autoimmune, neurology and/or
have a proven track record of being a results-oriented leader and will have 5+
yrs. leading, managing, and developing program related teams; prefer prior
Project Team Leader experience.