Annexon Biosciences is a clinical
stage biotechnology company focused on developing novel inhibitors that are
designed to block C1q and the entire classical complement pathway. We are
pioneers in targeting C1q, the initiating molecule of the classical complement
pathway. By stopping the start of this pathway, our C1q inhibitors are designed
to treat multiple complement-mediated autoimmune, neurological and ophthalmic
diseases of the body, brain and eye. Annexon is headquartered in South San
As the leader
of one of our therapeutic franchises, the Project Team Leader will provide strategic scientific, business and operational
leadership and direction of the R&D development and advancement of
Annexon’s portfolio. In addition to developing and driving a comprehensive
lifecycle portfolio strategy, the Project Team Leader shall be responsible for
leading a cross functional leadership team of both internal and external
resources in all aspects of development pre-IND stage through late stage
development, ensuring consistent high quality output from the team and
achievement of program goals and objectives as well as drive effective
execution of such strategies by leading the cross functional team’s engagement,
integration, coordination and communication across functional lines. Duties for this role also include managing
R&D partnerships, helping to build necessary infrastructure for the R&D
organization and working with the executive leadership to create an environment
that supports rapid and high quality decision making (both for the portfolio
and the organization) and to identify, evaluate and find solutions for key
issues facing the programs on an ongoing basis. The Project Team Leader will
report into the SVP, Portfolio Strategy & Operations.
Partnering with internal and
external stakeholders to drive the development of a comprehensive strategic
plan through registration and pre-commercialization preparation, including
goals, budget and risk assessment.
Includes developing program vision, strategy, scope/focus, milestones,
risk assessment and management strategies, as well as project investment
Project Team focused on the development of Annexon’s clinical candidates, from
pre-IND through late stage clinical development and NDA submission for multiple
indications. Project Team shall include
representation from Research, Development, CMC, Regulatory, Quality, Commercial
Providing effective leadership
and direction to the cross functional Project Team, including scientific and
operational oversight of activities, budgeting and planning.
Utilizing his/her understanding
of disease biology, global drug development and portfolio management within the
field of Neuroscience and/or Autoimmune disorders to effectively lead the
Partnering with executive team
to develop operating framework within R&D, including with regard to the
Project Team to clarify and facilitate decision-making and escalation around
strategic direction, resource allocation, etc.
Partnering with functional
areas to identify and ensure adequate resources for timely completion of goals
and objectives. Ensuring team members
understand program objectives, specifications, deliverables, timelines, and
Driving the development and
implementation of lifecycle portfolio strategy and follow-on drug candidates
for multiple diseases.
Managing and communicating
program progress on a continual basis, identifying both cross-program and
cross-functional issues, resource issues, timeline issues, and budget issues.
Works on significant and unique
issues where analysis of situations or data requires an evaluation of
Exercises independent judgment
in methods, techniques and evaluation of criteria for obtaining results
Participates in corporate
development of methods, techniques and evaluation criteria for projects,
programs and people
Ensures budgets and schedules
meet corporate requirements
Creates formal networks
involving coordination among groups.
Regularly interacts with executives and/or major internal and external
Works on abstract problems
across functional areas of the business.
Identifies and evaluates
fundamental issues for major function areas through assessment of intangible
variables. In-depth knowledge of functional areas, business strategies and
Interacts internally and
externally with executive level management requiring negotiation of matters to
influence policymaking bodies both internally and externally.
roadblocks and issues of conflict and maintains open lines of communication in
problem solving and resolving issues and conflict.
· Leadership: Experience leading and motivating teams in a matrix
environment is required. Proven interpersonal skills with ability to influence,
resolve conflict and drive decisions among internal cross functional teams,
executive management, and external teams.
· Strategic Agility: Ability to develop and execute complex
· Collaboration/Relationship Management/Influencing: Ability to effectively collaborate in and
across multiple functions, and with internal and external stakeholders of
various backgrounds and skill sets. Skilled in establishing a
collaborative and respectful environment. Demonstrated skills in persuading senior
leadership on strategy, initiative(s) implementation, and decision-making.
Influences and motivates others to achieve objectives.
· Decision Making: Strong
decision-making skills taking multiple perspectives into account and analytical
skills are required; exercises sound business judgment that has broad
· Communication: Excellent
communication skills (both orally and written) is critical to the success of
Business Excellence: good at
developing the processes necessary to get things done, knows how to organize people and activities and knows what to
measure and how to measure. Demonstrated ability to interpret data into
· Negotiation: Proven negotiation
skills that effectively drive discussions and decisions to desired end-results
that have broad organizational impact.
The successful candidate should
have an advanced degree in life sciences or medicine (PhD or MD) and/or commensurate
experience. He/she will have at least 10
years of industry experience in drug development, including experience in early
phase non-clinical and clinical drug development, regulatory knowledge and
pre-commercial market preparation.
Prefer scientific or industry
experience within the autoimmune, neurology and/or ophthalmology field.
Will have a proven track record
of being a results-oriented leader and will have 5+ yrs. leading, managing, and
developing program related teams; prefer direct Project Team Leader experience.